lithium aluminium tetrahydride; tetrahydrofuran; diethyl ether;
reactants are commercially availlable.
novartis pharma gmbh, wo2005/77932, a2, (2005) 2-methyl-thiazole-4-carboxylic acid ethyl ester (966 mg, 5.64 mmol) is dissolved in 5 mi of diethylether and cooled to-78°c. a 1 m solution of lithium aluminium hydride in thf (16.9 ml, 16.9 mmol) is added dropwise and the mixture is sirred for 3.5h at-78°c. the mixture is quenched at this temperature with a saturated solution of sodium sulphate and is allowed to warm up to room temperature, followed by extraction with ether and evaporation. yield : 670 mg (92percent). ms (es i) : 130.0 [m-h]-, 1h-nmr (cdc13) : b (ppm) 7.20 (s, 1h), 5.27 (dd, 1h), 4.50 (d, 2h), 2.62 (s, 3h).
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