the synthesis process is as follows:
sodium hydroxide; sulfuric acid; chlorobenzene; aluminium trichloride
reactants are commercially availlable.
sterling drug inc., us4032527, a1, (1977) a. a mixture of phthalic anhydride (60 g.), n,n-diethyl-m-toluidine (162.8 g.), aluminum chloride (1 20 g.) and chlorobenzene (360 ml.) was heated (75°-95°c.) during one and one-half hours, then dilut ed with water (200 ml., then more). more chlorobenzene (200 ml.) was added and the chlorobenzene layer was separated and steam distilled. addition of sodium hydroxide solution (10percent) to a solutio n of the residue in dilute sulfuric acid (20percent, 250 ml.) afforded 2-(2-methyl-4-(diethylamino)benzoyl)benzoic acid (iv: y2 = ch3, y'4 = (ch3 ch2)2 n, z4 = z"5 = z"6 = z7 = h).
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