reactants can be synthesized in 1 step.
matthews, donald paul, us2010/69404, a1, (2010) in a 3-neck round bottom flask mix 2-amino-5-methyl-thiazole-4-carboxylic acid ethyl ester (62.9 g, 338 mmol) and thf (630 ml). heat to reflux and treat the reaction mixture with isoamyl nitrile (52.6 g, 60.1 ml, 449 mmol) dropwise. upon completion of the addition, stir the reaction at reflux for 1 h, then concentrate the reaction mixture by rotavap (hi-vac) to give 70 g crude product as a thick o range oil. purify on silica gel (400 g, 20-45percent etoac/hexanes) to afford 39.47 g (68percent) of the title compound as a yellow solid. lc-es/ms m/z 172 (m 1), tr=1.5 min.
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