carbamic acid; palladium 10 on activated carbon; methanol;
reactants are commercially availlable.
zheng, xiufang, wo2015/22301, a1, (2015) to a solution of 5-nitropyridine-2-carbonitrile (7.0 g, 46.9 mmol) in methanol (150 ml) was added 10percent palladium on carbon (2.0 g) and carbamic acid (7.0 g, 115 mmol). after being heated under reflux for 16 hours, the resulting mixture was filtered and the filtrate was concentrated in vacuo. the residue was dissolved in water (150 ml) and the resulting mixture was extracted with ethyl acetate (150 ml x 3). the organic layer was dried over sodium sulfate and concentrated in vacuo to afford 5.1 g of 5-aminopyridine-2-carbonitrile (yield was 9 1.3percent).
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