产品推荐：2-尊龙凯时app

名称：2-氨基-4,5-二甲基噻唑溴酸盐
英文名称：2-amino-4,5-dimethylthiazole hydrobromide
分子式：c5h9brn2s

规格：95%

用途：基础原料、有机中间体、医药中间体

合成路线如下：

n-butyllithium; tetrahydrofuran; tetrahydrofuran;

reactants are commercially availlable.
eisai randd management co., ltd., us2011/86882, a1, (2011) production example 20-12,5-dimethyl-1,3-thiazole to a tetrahydrofuran (30 ml) solution of 2-methylth iazole (1.00 g, 10.1 mmol) was added n-butyllithium (4.02 ml, 10.6 mmol) dropwise at -78°c. and the mixture was stirred for 30 minutes. to the mixture was added iodomethane (0.69 ml, 11.1 mmol) and the mixture was warmed to room temperature. after the reaction was completed, water was added to the reaction mixture while cooling on ice, which was extracted with ethyl acetate. the organic layer was washed with brine and dried over anhydrous magnesium sulfate. the mixture was filtered to yield a f iltrate, and distilled off under reduced pressure to obtain the title compound (864 mg, 7.63 mmol).1h-nmr (cdcl3) delta: 2.41 (s, 3h), 2.64 (s, 3h), 7.24 (s, 1h).