reactants are commercially availlable.
liang, yanke, wo2016/23014, a2, (2016), (315 pag.) 2-chloro-n-methylpyrimidin-4-amine (18) to a solution of 2,4-dichloropyrimidine (5.0 g, 33.79 mmol) in anhydrous thf (50 ml) was slowly added 2.0 m methylamine solution in thf (42.2 ml, 84.48 m mol) at -40 °c. the reaction mixture was stirred at 0 °c for 4 h and partitioned between chcl3/2- pr opanol (4/1) and water. the organic layer was dried over anhydrous sodium sulfate, filtered through a pad of celite, and concentrated under reduced pressure. the residue was purified by column chromatography on silica gel (100percent dichloromethane) to afford 2-chloro-n- methylpyrimidin-4-amine (2. 8 g, 58percent yield) as a white solid. rt = 1.15 min;1h nmr 600 mhz (dmso-d6) 8.02 (s, 1h), 6.22 (m, 1h), 2.86 (d, j = 4.8 hz, 3h) ppm; ms m/z: 144.12 [m 1].
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