hydroxylamine hydrochloride; sodium carbonate; scandium tris(trifluoromethanesulfonate); water;
reactants are commercially availlable.
tetrahedron letters, vol. 52, 44, (2011), p. 5851 - 5854 general mw procedure: a mixture of sc(otf)3 (10 mol percent, 49 mg), aldehyde (1 mmol), nh2oh*hcl (1 mmol, 69 mg) and na2co3 (1 mmol) was placed in a safe pressure regulation 10 ml pressurized vial containing h2o (1 ml). the vial was sealed with a 'snap-on' cap and irradiated in a single-mode cem discover bench mate microwave reactor at 300 w and 135 °c for 15-35 min. after the reaction was complete (periodic tlc monitoring), the mixture was allowed to cool to room temperatur e and was extracted with etoac (3 .x. 10 ml). the combined organic phase was dried over na2so4, filtered and the solvent was removed under vacuum. the leftover residue was purified by column chromatography on silica gel (etoac/hexane 3:7 as eluent) and then characterized based on their physical and spectral data.
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