potassium acetate; 1,4-dioxane; (1,1'-bis(diphenylphosphino)ferrocene)palladium(ii) dichloride; 1,1'-bis(diphenylphosphino)ferrocene
reactants can be synthesized in 1 step.
wang, hui-ling, us2005/182067, a1, (2005) (b) 4,4,5,5-tetramethyl-2-(4-trifluoromethyl-cyclohex-1-enyl)-[1,3,2]dioxaborolane. to a solution of trifluoro-methanesulfonic acid 4-trifluoromethyl-cyclohex-1-enyl ester, example 1(a), (6.1 g, 20.5 mmol) in dioxane (100 ml) was added bis(pinacolato)diboron (5.6 g, 22 mmol, aldrich), potassium acetate (5.9 g, 60 mmol), pdcl2(dppf) (315 mg, 0.6 mmol, strem) and dppf (332 mg, 0.6 mmol, strem) under nitrogen atmosphere. the reaction mixture was heated at 80°c. with stirring for 18 h, cooled to ro om temperature, and filtered through celite.(r).. the filtrate was evaporated in vacuo and the resid ue was purified by silica gel column chromatography (10percent ethyl acetate/hexane) to give the title compound as a white amorphous solid. ms (esi, pos. ion.) m/z: 277 (m 1).
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