reactants are commercially availlable.
lyle, terry alan, us2003/158218, a1, (2003) a mixture of 7.5660 g (45.25 mmol) 4-hydroxy-2-(methylthio)pyrimidine-5-carbonitrile and 40 ml (429. 14 mmol) of phosphorus oxychloride was heated at 110°c. for 3.5 h and then concentrated in vacuo. t o the resulting residue was added and decanted boiling hexane (60 ml*4). the combined hexane fractions were concentrated in vacuo to give of 4-chloro-2-(methylthio)pyrimidine-5-carbonitrile as a yello w solid. 1h nmr (cdcl3, 400 mhz) delta 8.645 (s, 1h, arh); 2.625 (s, 3h, ch3); ms es m 1=186.0
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