reactants can be synthesized in 1 step.
velsicol chemical corporation, us3932410, a1, (1976) example 5 preparation of tetrahydro-1-(5-methyl-1,3,4-thiadiazol-2-yl)-3-methyl-6-methoxy-2(1h)-pyrimidinone tetrahydro-1-(5-methyl-1,3,4-thiadiazol-2-yl)-3-methyl-6-hydroxy-2(1h)-pyrimidinone (7 gram s), methyl alcohol (50 ml) and toluenesulfonic acid (0.2 grams) are charged into a glass reaction vessel equipped with a mechanical stirrer, thermometer and reflux condenser. the reaction mixture is t hen heated at reflux for a period of about 24 hours. after this time the mixture is stripped of unreacted alcohol under reduced pressure to yield a solid product. this product is then recrystallized to yield the desired product tetrahydro-1-(5-methyl-1,3,4-thiadiazol-2-yl)-3-methyl-6-methoxy-2(1h)-pyrimidinone.
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