reactants are commercially availlable.
novartis pharma gmbh, wo2007/48771, a1, (2007) di-t-butyl dicarbonate (1 equiv) and triethylamine (2.2 equiv) are added subsequently to 3-butene-1 -amine hydrochloride (1 equiv) in ch2ci2. the mixture obtained is stirred in an inert atmosphere for 24 hours at ambient temperature and que nched with an saturated aq. ammonium chloride solution. after extraction with ch2ci2, the combined organic layers obtained are dried, filtered and concentrated. t-butyl but-3-enyl-carbamate is obtained.
feel free to call us on
drop us a line anytime at
and we’ll get back soon.
come visit us at 南京市江宁区科学园乾德路5号