iron; acetic acid;
reactants are commercially availlable.
wyeth, us2007/72897, a1, (2007) methyl (4-fluoro-2-nitrophenyl)acetate (7.1 g, 33 mmol) and iron powder (7.4 g, 130 mmol) were combi ned in glacial acetic acid (65 ml) and heated at 100°c. after 2 hours, the cooled mixture was conce ntrated under reduced pressure. the residue was dissolved in hot ethyl acetate (100 ml), filtered through celite and washed with hot ethyl acetate (100 ml). the filtrate was washed with 1 n aqueous hy drochloric acid (3*100 ml) and saturated brine (100 ml), dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure to give a brown solid. trituration with 5percent ethyl ac etate-hexanes (100 ml) provided 6-fluoro-1,3-dihydro-2h-indol-2-one (4.8 g, 96percent) as a tan solid. ms (es) m/z 150 [(m-h)-].
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