波普医药正在热销：
别名：3,6-二氢-2h-吡喃-4-硼酸频哪醇酯
英文名称：3,6-dihydro-2h-pyran-4-boronic acid pinacol ester
分子式：c11h19bo3
cas no.：287944-16-5
分子量：210.08
结构式：
规格：97%
用途：基础原料、有机中间体、医药中间体
合成路线：
(1,1'-bis(diphenylphosphino)ferrocene)palladium(ii) dichloride; potassium acetate; 1,4-dioxane;
reactants are commercially availlable.
under an atmosphere of nitrogen, a solution of 4-bromo-3,6-dihydro-2h-pyran 10 (24.5 g, 0.15 mol), bis(pinacolato)diboron (42.0 g, 0.15 mol),1,1?-bis(diphenylphosphino)ferrocene-palladium(ii) dichlori de methylene chloride complex (1.25 g, 1.5mmol) and potassium acetate (44.5 g, 0.45 mol) in dioxane (350 ml) was heated to 80 oc for 3 h. water (50 ml) was added to the reaction mixture which then was extracted with ch2cl2 (3 x 30 ml). the combined organic extracts were washed with brine, dried over anhydrous sodium sulfate and evaporated under reduced pressure. the residue was recrystallized in c old hexane to yield the title compound 1 (20.6g, 0.098 mol, 66percent yield) as white solid. mp 61?6 2 °c (lit.11 60?61 °c); 1h nmr (400 mhz, cdcl3): delta6.53 (s, 1h), 4.20?4.18 (m, 2h), 3.77?3.74 (t, j = 6 hz, 2h), 2.25?2.23 (m, 2h), 1.27 (s, 12h); hrmscalcd for c11h19bo3 [m] 210.1427; found: 210.1429.