hydrogenchloride; hydrogen; methanol; ethanol; palladium on carbon catalyst
reactants can be synthesized in 1 step.
novartis pharma gmbh, wo2004/69256, a1, (2004) to a solution of 1-benzyl-piperidin-3-one (1g) in ch2ci2 (loml) is added [bis (2-methoxy- ethyl) amino] sulfer trifluoride (1. 84ml) at 0c, and stirred for 1.5hr at room temperature. the reaction mixt ure is poured in aqueous nahc03 and extracted with ethyl acetate. the organic layer is successively washed with h20 and aqueous naci, dried over mgs04, and concentrated in vacuo. the residue is purifi ed by column chromatography to give a colorless oil. the oil and pd/c (5percent w/w on activated carbon, 100mg) in hci in etoh/meoh (50ml) is stirred for 22hr under h2 atmosphere. the reaction mixture is filtrated through celite pad. 4the filtrate is added hci in etoac, then concentrated in vacuo to provide the title compound.
feel free to call us on
drop us a line anytime at
and we’ll get back soon.
come visit us at 南京市江宁区科学园乾德路5号