lithium hydroxide monohydrate; water; tetrahydrofuran;
reactants are commercially availlable.
stokes, neil, wo2015/155549, a1, (2015) (a) 5-bromo-1 ,3-thiazole-4-carboxylic acid to a stirred solution of methyl 5-bromo-1,3-thiazole-4-carboxylate (5.00 g, 22.52 mmol) in thf (80 ml) was added an aq. solution of lioh.h20 (2.70 g, 112.58 mmol) in h20 (20 ml). the reaction mixture was stirred at room temperature for 18 h. dcm (50 ml) and h20 (20 ml) were then added and the reaction mixture acidified to ph?2 with 2m aqueous hci, follow ed by extraction with dcm (3 x 20 ml). the combined organic extracts were washed with brine (20 ml), dried over mgso4, filtered and concentrated under reduced pressure to give 5-bromo-1,3-thiazole-4-c arboxylic acid (3.09 g, 66 percent yield) as a yellow solid, which was used without further purification.lc-ms (method d) 208.3/210.3 [m h] rt 1.36 mm
feel free to call us on
drop us a line anytime at
and we’ll get back soon.
come visit us at 南京市江宁区科学园乾德路5号