reactants are commercially availlable.
qiu, jian, us9138427, b2, (2015) synthesis of compound 11-2 (0399) compound 11-1 (5.0 g, 2.86 mmol) was added portionwise to pocl3 ( 15 ml) at 0°c. during 10 min. the reaction mixture was stirred at 120°c. for 4 h, then cooled to r oom temperature and added to ice-water (100 ml). sat. na2co3 was added to adjust ph=7 and extracted with ethyl acetate (200 ml?4). the combined organic layers were dried over na2so4, filtered and conc entrated to afford 11-2, which was used in the next step without further purification (4.50 g, 80percent).
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