triethylamine; phosphoryl chloride;
reactants can be synthesized in 1 step.
applied research systems ars holding n.v., wo2007/23186, a1, (2007) to a solution of l,4-dihydropyrido[3,4-]pyrazine-2,3-dione (9 g, 0.055 mol) in pocl3 (90 ml) is added et3n (6.7 g, 0.066 mol) and the reaction mixture is refiuxed for 2oh under n2. the reaction mixtur e is cooled down and carefully quenched with ice-water (1 kg) and the product is extracted with etoac (3x150 ml). the combined organic layer is washed with water, dried over mgso4 and evaporated under reduced pressure to afford 6g (54percent) of the title compound as a solid. tlc - chloroform / methanol (9/1): r7= 0.8, hplc (max plot) 98percent.
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