名称：5-甲基-3-异噁唑羧酸乙酯
英文名称：ethyl 5-methylisoxazole-3-carboxylate
分子式：c7h9no3
分子量：155.15
cas no.：3209-72-1
结构式：
规格：95%
用途：基础原料、有机中间体、医药中间体
合成工艺如下：
hydroxylammonium sulfate; ethanol; toluene;
reactants are commercially availlable.
pfizer inc., ep150984, b1, (1991) (i) ethyl 5-methylisoxazol-3-carboxylate a mixture of 0.16 mole ethyl 2,4-dioxovalerate and 0.08 mol e hydroxylamine sulfate, 50 ml ethanol and 70 ml toluene was stirred at 40°c. for four hours. the mixture was cooled to 15-20°c., 1.8 g of concentrated ammonium hydroxide added and stirring continu ed at room temperature for 60 hours. the mixture was poured into water/toluene, the aqueous layer e xtracted with toluene, the organic layers combined, washed with brine and dried (na2so4). evaporation of solvent in vacuo gave a yellow liquid which was distilled to afford 14.68 g of product, b.p. 12 0-124°c. at 30 torr which crystallized upon standing.