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eschenmoser盐,二甲基亚甲基碘化铵是一个很强的二甲氨基甲基化试剂,用于制备

rch2n(ch3)2一类化合物。烯醇化物、烯醇硅醚及更酸性的酮都可有效的进行二甲氨基甲基化用于mannich反应。


机理



反应实例




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参考文献


1. schreiber, j.; maag, h.;hashimoto, n.; eschenmoser, a. angew. chem. int. ed. 1971,

10, 330–331.

2. kleinman, e. f. dimethylmethyleneammoniumiodide and chloride. in encyclopedia

of reagents fororganic synthesis (ed: paquette, l.a.) 2004, wileynew york. (review).

3. nicolaou, k. c.; reddy, k.r.; skokotas, g.; sato, f.; xiao, x. y.; hwang, c. k. j.

am. chem. soc. 1993, 115, 3558–3575.

4. lidia kupczyk-subotkowska,l.; shine, h. j. j. labelled compd. radiopharm. 1993,

33, 301-304.

5. saczewski, j.; gdaniec, m. tetrahedronlett2007, 48, 7624–7627.

6. hong, a.-w.; cheng, t.-h.;raghukumar, v.; sha, c.-k. j. org. chem. 2008, 73,

7580–7585.

7. cesario, c.; miller, m. j. org.lett2009, 11, 449–452.

8. crimmins, m. t.; zuccarello,j. l.; ellis, j. m.; mcdougall p. j.; haile, p. a.; parrish,

j. d.; emmitte, k. a. org. lett. 2009, 11,489-492.



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