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weinreb酮合成法是有机金属亲核试剂(如:格氏试剂、有机锂试剂)与weinreb酰胺(n-甲氧基-n-甲基酰胺)反应制备酮的方法。weinreb酰胺与金属氢化物(如:氢化铝锂)反应也是制备醛的标准方法。

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反应机理

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反应实例

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参考文献


1. nahm, s. and weinreb, s. m., tetrahedron lett., 1981, 22, 3815.

2. inokuchi, t. and kawafuchi, h., j. org. chem., 2006, 71, 947.

3. groesbeek, m. and smith, s. o., j. org. chem., 1997, 62, 3638.

4. mentzel, m. and hoffmann, h. m. r., j. prakt. chem., 1997, 339, 517.

5. dias, l. c.; jardim, l. s. a.; ferreira, a. a. and soarez, h. u., j. braz. chem. soc., 2001, 12, 463.




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