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波普医药正在热销:

别名:5-碘-2-甲氧基苯甲酸
英文名称:5-iodo-2-methoxybenzoic acid
分子式:c8h7io3
cas no.:2786-00-7
分子量:278.05

结构式:image.png

规格:97%

用途:基础原料、有机中间体、医药中间体

合成路线如下:

n-iodo-succinimide; [(ph3p)au]ntf2; dichloromethane; toluene;

reactants are commercially availlable.
synlett, vol. 25, 3, (2014), p. 399 - 402 general procedure: to a stirred solution of the substrate (1 mmol) in ch2cl2 or (ch2cl)2 (0.1 m) were added ph3pauntf2 (0.025 mmol, 19 mg; complex ph3pauntf2 toluene, 2:1) followed by n-iodosuccinimide (1.1 mmol, 248 mg). the resulting solu tion was stirred at r.t. or under reflux until complete conversion of the starting material. after removal of the solvent under reduced pressure, the crude material was purified by flash column chromatography using different gradients of he xanes and etoac to obtain the pure desired products.

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